Hi Ryan,
Depending on how large your room is, what types of music you like to listen to and how loud you like to listen to it, a single PSB 250 or even two maybe too small.
What are the pros and cons of using the sub's preamp level inputs vs the speaker level inputs in this application?
In this case the pre level Inputs would allow you to use the PSB 250's low level input and output connection scheme that limits the level of the low frequencies reaching the mains. This setup would give you the most control and should be far easier to integrate than the other hookup methods.
does an inline sub like this do any processing, will it color the mids and highs in some way or is it just a clean pass-through in terms of sending the signal along to the speakers?
I did not read the owners manual all the way through but at the price point of the PSB 250 I highly doubt that there is any processing happening so it should be a clean pass through to your mains with the exception of the limiting of the level of the low frequencies below your chosen crossover frequency.
You may also need to plug the ports on the RP8000F's to get the best results.
I noticed that the RP8000F's can be Bi-amped. You may get satisfactory results with this option also if you can control the input gains of your amplifiers.