It really doesn't make too much difference which you design you pick. Both have their pluses and minuses. It's far more important that you like the way a speaker sounds with your equipment than focusing in on any specific design element. People who say they think one method is better than the other haven't listened to enough speakers to make such a sweeping statement.
3 way vs. 2 way
I currently have Mirage M5si bi polar speakers, I believe these have two tweeters and two 6inch drivers. For my room size I want to go to a conventional speaker. I would also like to give a high end store in my area the business as the owner is a friend. He carries Totem and B&W. I notice may of the Totems have only a tweeter and a driver. Can I get as good sound out of smoething like that as compared to a speaker with 3 or 4 in the cabinet?