I used to have 1 REL sub, tried 2 Rythmiks F12 and preferred the latter, then added 2 additional F12 for a nice improvement, then added a miniDSP 4x10HD and Multi Sub Optimizer (MSO) for an even better result. Very much in line with above posts.
Multiple subs.allow for smoother frequency response across morecseats in the room. MSO enables a flat response across several seats. It does require a measuring mic, though.
One suggestion is to consider two Rythmik F8 under/very close to your LS50. F8 can be crossed much higher (up to 250Hz but you don't need that much). You could run F8 say 20 to 150Hz and two F12 from 20 to 60Hz.
I had my Rythmiks for about 12 years without issues. And the same folks keep replying my questions at Rythmik, which is nice.