For me, I have never been happier than having bi-amp with 3 way active crossover.
I can split out sub, then use a solid state amp for lows, and a couple mono tube amps for mid-highs. Since the input frequency to each amp is limited, the signal coming out of each amp is “cleaner” for that range and allows each to “shine”. Good large gauge, shielded and as short as possible, wire that offers minimal resistance also seems to improve the performance.