If you do amp to sub and amp to main speaker wiring, you don't really need anything heavier than magnet wire to the sub. The speaker ins on a sub have very high input impedance and so use little real power.
You probably don't want to really use magnet wire, but you also don't need anything approaching the size or quality you feed the mains with.
You probably don't want to really use magnet wire, but you also don't need anything approaching the size or quality you feed the mains with.