Should I got full tubes or stick with hybrid amps?

Tone controls can be the real stumbling block since, for some un-fathomable reason, most designers have decided they are no longer required. Another factor is the type of sound you are looking for. You've stated that you don't like fatiguing highs. Depending on the tubes, even full tube set ups can sound harsh. One unit I will throw out there for you to consider is the Vincent SV-237MK hybrid integrated amp. It has a three tube pre amp stage with a very good solid state amplifier. Two of the tubes are 6N1P-EV's which pretty much don't have many sound changing replacement options. The third tube is a 12AX7 which gives you lots of options to change the sound. Besides bass and treble controls, it has a tone bypass, and something that used to be standard on just about everything, a "loudness" switch. I have owned one for awhile now and it is an excellent sounding integrated. At 150 wpc at 8 ohms, it will drive any speakers with ease.

Tubes Harsh? Huh?

I’ve used Tubes since 1973, 47 years, harshness never entered my ears.

always in the 30-35-45 wpc size (4 power tubes total)

Fisher Mono Blocks 80Z (EL37, substitutes)
Fisher Receiver 500C; 800C (7591, substitutes)
Current Cayin A88T 6550 or KT88

I think I put EL34’s in the Fisher Mono’s, -5 wpc, a vauge memory

Fisher’s used lots of 12...
Cayin uses 6....
Other Cayin’s now use 12 ....

I found both the pre 6’s and the Power tubes brands definitely sounded dirrerent/preferrable, but none sounded harsh.

I’m thinking I like the 6.... better than the 12 ....

You seem to be forgetting that those big output tubes have smaller tubes driving them. Those smaller tubes CAN sound harsh and pass that harshness on to the output tubes. I find that it is mostly the new production tubes that can impart harshness, but some NOS can also have those characteristics. If those tubes didn’t affect the tone, nobody would bother rolling them to find the best sound. It should also be noted that tubes for the most part are a lot more finicky when it comes to the speakers they sound best with. 

@hilde45   
Didn't think about the fireplace or the pics.  Definitely need to look at some acoustic panels.

@elliot  
Great suggestions.  I only listen from my desk (in this room).The black chair just sits there. Considering getting rid of it.  I don't use it. Equipment is to the left of my desk. Sitting on a table.  Thanks for the tip about 4 power tubes.  That will probably change what I can look at.  

@hobo1452   
I'll take a look at the Vincent.  I heard (somewhere) that they soldered their tubes and weren't very helpful if you wanted to change them or needed other support.  Was your experience with them different?  

EDIT: The Vincent is almost $3k.....  dang.  I like everything else about it though! Tone controls and loudness are sweet. 

@soundchasr, I’d place two nice dog beds in the middle. Good absorption, especially when occupied.