Most achingly-beautiful music

Does he have a friend for me- Maria Mckee, Bach Cello suites- Yo Yo Ma, Company from Rickie Lee Jones first album.

Gregorio Allegri; Miserere mei, Deus. Haunting, eerie, evocative. Sent chills up my spine.

ANY early Cocteau Twins,Dead Can Dance, or Chameleons UK

I nominate whatever it was the opera troupe was singing in the concert scene in Hannibal. Very haunting...

I can't name the three *most* affecting: that various depending on my mood and a host of other circumstances. But here are a few very random pieces that came to mind as very moving:

Beethoven's 5th, 6th, 7th symphonies
Bach's Goldberg variations
Mozart's Piano Concertos 23, 21
Bizet's Carmen and Le Arlessienne Suites
Rachmaninov's 3rd piano concerto
Tchaikovsky's violin concerto, symphonies 4-6
Mendelssohn violin concerto, Italian symphony, octet
Schubert trout quintet
Brahms Hungarian Dances
Haydn Symphony No. 94
Bach solo cello suites
Strauss waltzes
Bolling Suites for Flute and Jazz Piano
Mussorgsky's Night on a Bald Mountain

A smattering of my perhaps "cheesier" choices ;-) :
"Meeskite" from the musical Cabaret
Butterfly Kisses by Bob Carlisle
Bohemian Rhapsody by Queen