As the Druid V's are 16 ohms, they would likely be better suited for a tube amp with 16 Ohm taps. I recently taked to Sean and Zu and that is specifically what he told me. I do know that Sean is a huge fan of the Pass amps and I bet he would be able to answer your question better than anyone.
If anyone has compared the Druid to Def mkIII or MkIV's I would love to hear the comparison also. I'm a current DefIII owner and would love to compare the two.