Great responses, but I did not see any Eddie Van Halen votes? With the continuing mediocrity of the current Van Halen config, his legend seems to be diminishing. But the guy is really a brilliant musician.
I'm going to go out on a limb and put the into to "Hot for Teacher" up for consideration. Not just speed, but inventiveness, and creating a whole new sound.
After that, I'm onboard with Roger Waters on "Comfortably Numb". Great licks.