Will my QUADs drive Spendor S100s?

I currently use the S100's and formerly used the Quad's but not together. So long as you do not have a very large room or try to play very loud levels I see no reason why they would not work. Most of the time you are only using a few watts and the 303 was an exceptional amp for it's time. If you like the way it sounds on the Prelude then you should like the S100's even better, unless the room is too small for them. Biamping will improve the sound. Bare wire will do a better job than the jumpers Spendor provides.