@jasonbourne71 I always enjoy your perspective. However, the laws or physics apply to everything, regardless of whether to produces an effect one can hear. The are some theories that apply and are published. One is conductor grain structure that will set up in angular patterns that potentially affect electron flow - causing more resistance in one direction than the other. The manufacturer usually marks the direction. I have read this but no one presents data. Second, some manufacturers only connect the shield one end of the cable, theoretically to help prevent ground loops. The shielded connection end should be connected to source. The manufacturer usually marks the end connected to the shielding. So theoretically physics applies and is unchanged. I agree that practically, the physics is not auditable in my experience.
@argee Sorry I have no experience with Transparent cables. There are some conventions to consider.
Interconnects - red = right channel.
Speaker wire - red = positive terminal
Digital RCA connectors - generally not directional, or as marked by mfg.
USB - Poke yoke design. Directional with physically limited connectors