Its honestly a mixed bag
I put an AQ Dragon HC power cable on a gryphon amp and wasnt sure there was a difference. This is a very expensive cable to not hear much over a stock cable
On the flipside
the biggest difference i ever experienced was when i upgraded speaker cables a while back.I went from plain installer grade wire to a used pair of AQ Volcano.
it was such a massive difference that i reinstalled one speaker with cheap wire and the other with upgraded wire to demonstrate to some cable denier friends
i even made a video about it where i would go back and forth between the two. It was such a huge difference that even playing it back on my cellphone the gap was so large it could have single handily ended the cable debate as anyone not deaf could hear the difference
now i run stealth audio cloude 99. Once again this is a big difference. They use a helium dielectric and are ridiculously fast and airy silver cables
it affords me the ability go with more “chocolate” upstream