Ultimately it's about the trade off and priorities. Five identical amps all around will make it easier to tonally balance all the channels. 2+3 may be trickier to set up, but it will be superior in two channel music play back.
You should note that even with five identical amps, unless your speakers are also identical you won't automatically get tonally balanced set up. You'll notice the imbalance immediately when you play white noise on each channels if your center speaker is not identical to LR fronts. You'll most likely need to adjust the gain for each channels. If you have room EQ on your processor it would help with the imbalance.
Having said that, X3 and X350 will have more similarity than difference. I have never felt that I needed more power when I was drivng B&W 804 Nautilus speakers with X3. YMMV.
You should note that even with five identical amps, unless your speakers are also identical you won't automatically get tonally balanced set up. You'll notice the imbalance immediately when you play white noise on each channels if your center speaker is not identical to LR fronts. You'll most likely need to adjust the gain for each channels. If you have room EQ on your processor it would help with the imbalance.
Having said that, X3 and X350 will have more similarity than difference. I have never felt that I needed more power when I was drivng B&W 804 Nautilus speakers with X3. YMMV.