Especially if you have Lead in your ears.
The question was framed in such a manner so as to specifically not ask about hearing, auditory perceptions or any possible psycho-acoustic effects.
This was possibly accidental, of course.
What makes the biggest difference in sound quality?
When making changes or adding things to your system, what makes the bigger difference in sound quality on preamp‘s and power amps? Interconnects, speaker cables, power cords, or fuses?