True RMS takes time-varying and nonsinusoidal waves into account. This isn't a big deal when you are measuring line voltage because the 60Hz cycles are very regular but when you measure frequency-varying or complex waveforms, you need a much smaller calcualtion window - which is casually called "true RMS."
If you are getting a digital multimeter (DMM is the common abbreviation), I would recommend Fluke or Tektronix. I am partial to Fluke but the difference between the two is about like the difference between Ford and Chevrolet. Higher priced versions have better resolution and bandwidth (sound familiar?) and so they are "true RMS" capable, and clearly labeled as such. It just means they are more accurate but is the difference worth the extra cost? Well, you know what an audiophile would say.... :)
Arthur