As mentioned above, I agree that there are many different things that can cause listener fatigue, and I've found it's usually electronics, wires etc. too. John_1 has a good list, But one more: as the tubes in my pre-amp reach the end of their useful life, they produce brighter, harder upper mids and low treble that give me headaches. Of course putting in new tubes takes care of the problem-- it took me awhile to figure this out though. Non-fatiguing speakers between $2000 & $4000?-- I'd nominate Vandersteen 3Asigs. at $3500., or std. 3As at $2800. Good Luck. Craig.