If the volume is turned a long way up a low level hiss will usually be audible if you put your ear close to the tweeter. The hiss is a noise product of the amplifier but will be at a very low level relative to that of any signal that is connected (don't connect a signal at that volume level). The level of the hiss can be defined as its level relative to that of the signal - signal to noise, S/N, ratio. In a well-designed amplifier the noise level will be less than 1/1000th of the signal level.
All amplifiers generate noise, but if the amp is functioning correctly it will always be inaudible from the listening chair at any sensible volume level.