Like almost everything involving vibration damping/control, it is a matter of tuning, so there is no definitive answer. I've tried various speakers on damping platforms (the entire bottom of the speaker is in contact with a platform designed to transfer vibrations to the platform where the energy is dissipated as heat) and also tried the same speaker with spikes designed to transfer that energy to the floor. In some instances damping the energy sounds better (tighter bass), in others, transfer to the floor sounds better (excessive damping can make some speakers sound lean or "dry" sounding). It is really a matter of trial and error and personal taste.
Generally speaking, if you have a suspended wooden floor, and the bass sounds a bit boomy or muddy, decoupling from the floor would help. If you couple with spikes, vibration is transferred from the speaker to the floor which acts as a sounding board that may make this energy more pronounced (and also delayed in time).
What works best for any one person depends on so many factors that I find the best advice is to try different approaches.