Very large room HT

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TV..? Dude, with a room that size, you have to get a projector. I'm sure if you check the Videophile laws in your state, you'll find that it is illegal to have a room that size without a big screen and a projector.
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Since you have limited choices for listening to new equipment, you may want to try something used from Audiogon, or a direct manufacturer with an in-home trial period. If it's Audiogon, you can always resell.

I'm a B&W fan, but they need a high-current amp to really sing. I'm not sure that best buy would have anything appropriate. There are always great options on Audiogon.

My room is just as big as yours and I power my room with all Revels. It's utterly fantastic. I suggest--strongly--you consider auditioning the Revel Performa 3 line. They will make you very happy in both music and movies. You'll get the dynamics and the ability to move the air needed in that space. You can also look to Emotiva amps to power everything you need. If you don't want to consider Emotiva, then think about Rotel's class A/B amps that they just released. For the preamp, think about an Integra, Marantz, or at the upper end of your budget you can spring for an Anthem 50v 3D edition. You should be able to do everything you need for 20k with those electronics and speakers and not look back.

Thanks for quick response.
80 % HT dvd etc and 20% music Stereo...
Sitting 12 feet away from my TV /
All that in the middle of this large living area.
I do regard the internet as a major source of music.
Unfortunately the only shop in town is Best Buy.
And they sell B&W and Paradigm speakers .....

Yeah, that's a large room. But you have the budget to fill it with good sound.

My first question would be if the system will be strictly for HT (movies, TV) or for music too? This will determine the type of speakers you should be shopping for. And a 5.1 or even a 5.2 set of quality speakers should be the very first thing you should decide upon. I would allocate up to 10K of the budget for a 5.1 set; maybe up to 11-12K if you go 5.2 with two subs.

Once you decide upon the speakers, use the balance for everything else. Find a suitable 5 channel power amp that will drive them to the levels that you want to listen at. Then get the pre/pro and finally the sources. Since you mentioned HT in your post, a Blu-ray player would be a given. OPPO that was mentioned above above makes excellent Blu-ray players that double as great CD and SACD players too. Right now the OPPO BDP 95 is being cleared out at $899 and besides SOTA Blu-ray performance, it has an analog CD section that would rival stand alone high end CD players at twice the price. Hope this helps.

Assuming that this is dual purpose (for 2 channel music and HT use), I'd really look for wide dispersion speakers all the way around. I'd also go 7.2 channel because - my guess is - this is a big enough space to justify that. This could be omnidirectional (like Ohm) or just a very wide dispersion design (like Gallo). A pair of Ohm 3000, a matching center and 4 on-wall surrounds would run (IIRC) app. $10K.

A pair of Gallo Ref 3.5 plus a matching center and 4 on-wall Strata surrounds would probably run about $1k less (unlike Ohm, you can sometimes find these discounted and you might come in even lower with Gallo).

A pair of excellent 12" sealed box subwoofers from either Rythmik or SVS would run a bit under. $1500.

Either way, call the speaker side of the equation $11K. (If you go 5.2, it'll save $2 to $3 k, depending on the brand.)

Since I'd personally use HDMI and decode audio in the pre-pro (rather than the player) I'd ignore the BRP's audio capability and buy the least expensive Blue Ray player whose video performance I like (and most are very very good, IMHO).

The dirt cheap ($100) Sony blue ray players produce IMHO excellent images (and I'd personally save the $ and go that way), but that may offend some sensibilities. I understand that the $1200ish Oppo BR players are highly regarded by many here and they have a more appropriate "pedigree", if that's important to you .

Let's say that that leaves +/- $8K for a pre-pro and multi-channel amp.

I'm a fan of Onkyo/Integra pre-pros ($1500 - $2500), but you could also check out the Anthem D2 which is more expensive but highly regarded. Any sufficiently high powered solid state amplification will work well with either set of speakers and I'd probably choose a multi-channel amp from the same manufacturer as the pre-pro so that the units' appearance matches.

Any of these combos should be comfortably within your stated budget and I think any of these set-ups will produce really good sound for 2 channel use in your large space, as well as excellent, uniform coverage for HT use.

First you need to decide how much to spend on what. Do you need a blu-ray player? Is it just movies or 2-channel music too? How far back do you want to sit?

Anyway, maybe 10K speakers, 1200 OPPO dvd player, 1500 amps, 2500 processor, the rest on wires and room treatment (which you'll need).