It’s obviously not the mixer of the sound is initially good with the mixer in the line up. I was eying that mixer a few years back - it’s top notch among rotary mixers.
I would set up a few experiments with the equipment running on 220 and the overheating transformers - then if the problem persists I’d look into tube swapping. If the mixer has a tape loop you may be able to connect the loop out to another input. After a few hours switch to the loop input to see if the problem persists.