It is my opinion that the length of the inconnects will make a difference, especially since you are removing the pre-amp from your system (you may lose some drive). The type or brand of interconnects make a difference too. I've heard varying results in systems with long runs using different interconnects. So far, the Nordost Quattro Fil or Valhalla cables performed well in systems with long runs, although these ICs are extremely costly.
I've had very good results in my system using an amplifier with a volume control, replacing my pre-amp. That is another alternative.
I've had very good results in my system using an amplifier with a volume control, replacing my pre-amp. That is another alternative.