tubegb
In general Audio Research recommends changing/replacing output tubes in their amplifiers every 2000 hours. Assuming you have the owner’s manual, you should be able to confirm same. Another suggestion would be to periodically check the individual output tube bias.
Audio Research recommends changing tubes every 2000 hours in their amplifiers that use KT120s and 6550WE (Ref 250 and Ref 75). With the newer amps (250SE, 75SE, 160M, 160S) running KT150s, the manual now recommends changing the KT150 every 3000 hours. The 2000 hour recommendation however still holds for the 250SE and 75SE that still have 6550WEs. The newer 160 series amps now have auto-biasing.