I can attest the move from Gen 5 Super to Gen 6 Ultra in speaker and interconnects was indeed startling. It was as if my system could go magically lower in frequency response than it had before. The weight of the bottom notes was more present than it had been before. Also the space between instruments as very noticeable.
With Ref and/or Opus level Transparent I would expect equal measures of improvement. At this price point make sure you can home audition. This was never a problem in the hey day of HiFi and Transparent had their home audition kit. I would look to see if this is still possible or give them a call up in Maine. They are a small company and should be able to guide you well.
I am very fond of their products and while gear has come and went, Transparent Cable is the only thing that has been a constant since 1997.