I have the exact same setup as you have and I have achieved a great sound. Go for it and work with it...too often we expect to plop great gear in a room (any room) and get great results. With care and system matching you should be able to achieve more than satisfying sound.
The space between the speakers
I would like to invest in a high end stereo system. Something like the Wilson Audio Sophias driven by Audio Research electronics. I need to share the space though with our home theater which means that there will be a cabinet that holds the 52 inch tv with a pop up lift in back and electronics in front between the speakers. The cabinet is 5.5 ft wide by 3 ft deep by 45 inchs tall. I can position the front of the speakers a little in front of the cabinet (6 to 12 inches). My question is: Is it likely that I will be able to get good enough sound out of the speakers in this situation to warrant the investment or is the cabinet a deal breaker?