Suggestions: Best speaker/sub combo for Desktop PC

I actually am a professional musician (orchestral and choral conductor), so music is my life's work and passion, so a sub is important in the equation to get full-range sound...this will not be for casual background listening, but critical imaging. I have a set of LSA 2 speakers that I power with an Arcam SOLO integrated amp...so that's what I'm used to hearing...but I'm looking for something that I can use on my PC to approximate full-range sounds when I can't sit in front of my towers....

I am using for playback only for score study, and sometimes for pre-editing of recordings my choirs and orchestras have done...I don't do any editing outside of the studio and an SSL Console. I'll check out Orbaudio.com...thanks for the lead....

Ed...thanks for your very informative response, I do appreciate your inpute greatly! I'm going to do some investigation into the NHT system. If it works for me, I may even unload my new LSA 2 speakers and ARCAM Solo that I recently bought...I'm all about being more compact now without giving up a lot of sonic quality. I'll post my findings...thanks again!