I heard a pair of 20.1s supplemented by a pair of JL Fathom f212 powered subs, each sitting right next to a 20.1 panel. This was at a high end shop's open house. I could not detect any discontinuity, discrepancy in speed, lumpy response, or any of the other pitfalls for blending subs. They extended the slam, extension, and room-filling abilities of the 20.1s about as much as you could hope for.
Since this was a balls-out demo with near unlimited funds, I'm sure you could get much of the same effect in a normal-sized domestic room from one or two of their Fathom f110.
Since this was a balls-out demo with near unlimited funds, I'm sure you could get much of the same effect in a normal-sized domestic room from one or two of their Fathom f110.