Of course...but that's not what you asked. Going 240 all the way and then stepping down at the subpanel or going all the way amounts to the same thing. If it's a large house, and the stereo is far away from the main, you go off the subpanel. The only reason to do this is that the resistance is far less through the thick wires going to the sub. If the stereo is near the main, it's better to go straight. Either way, eventually you are connecting to your neighbors trash, so you need the I.T. HOWEVER....what problems does the I.T. cause,if any? Have you A/B'd with and without? What kind are you using?