The main problem is not given by the environment, but by the incorrect synergy of the components inserted between them, and many times the incorrect electrical phase.
By solving these problems, you can really feel the physical limits of your room.
Obviously, in a small room, you can not insert speakers that "need air around", as they would be suffocated.In addition, with a DSP software or an audio calibration process software like Dirac for example, you can intervene on the frequency response by fixing the problems.
But it is something that I prefer to avoid, as the end result will always be a compromise.