Speakers for a large room for around $1000

I didn't read every post here but it isn't clear what amp you intend to use - although I thought I saw something that indicated you might like tube gear (which is generally preferred, imo). With respect to tubes, there are lots of amp (and preamp) choices, but some speakers will need more power than others. If you happen to select some high efficiency speakers (100db efficiency or so), you could then look into low powered SET amps (I like 45s, but 2A3s and 300Bs are other possiblities). This would allow you to get great tube sound for perhaps less than medium to high powered tube amps. I think your biggest challenge is the WAF. If you could live with Vandy 2Cs (used in good condition), or Dahlquist DQ-10s (used in good condition) you would be looking at speakers well under $1k for the pair and you could get yourself a nice $1k or so ARC or other tube amp. Or if you could live with the Cornwalls (under $1k used vintage), you could get a 45 SET amp. Almost no speaker is going to sound very good pushed up against a wall or in a corner (although that's what Cornwalls were supposedly named for). Based on what you have written, I think you would like Vandy 2Cs if you could get permission to put them several feet out from the back wall. You could get yourself a vintage ARC D76A or D70MkII, or you could get yourself a Marantz 2230/45/70 receiver and I think you would be surprised at how good it would sound. Or you could put the same electronics on a pair of DQ-10s. I think you are down the tube path (given your guitar amp experience) and you really ought to get some speakers that will synergistically show off what a good tube amp can do.

One thing you will find is that all the good speakers and electronics in the world will only constitute some portion of the resulting sound. The room size, shape, and furnishings will drive a bunch of the results and the location of the speakers in the room will also drive a bunch of the results. Clearly, the speakers and the speaker interaction with the room are key considerations, none of which almost ever synchronizes well with the WAF.

Now you are headed in the direction of seriously good sound, although maybe not with a high WAF. Martin Logans are poplular electrostatics, but to do their magic they will want to be reasonably far out from the back wall (check the Cardas formula) and they won't resemble much else in the way of typically high WAF furnishings. I'm not sure how much ML speaker you can really get for $1k, but if you can relax the budget and the WAF specs, there is no doubt that in a decent room electrostatics and tubes can reproduce music beautifully. If you can consider MLs you might also audition some Soundlabs and Quads, and probably some Maggies (not electrostatics, but planars). Maybe your wife will think planars are cute :) and then you are in.

Ok Thanks for the clarification
The new ML design would seem to offer some promise
A listening session might be in order