Seeking advice on high res computer music: 4 Qs

After scanning the recent threads and posts, I do not see much discussion around playing high resolution music via computer. I enjoy the convenience of itunes, and I am intrigued by ads for high res downloads and mailable DVDs.

Is there a convenient way to continue to use itunes and also start collecting high res music? If not, what software have people liked?

Is there a preferred connection method? The last TAS indicated that USB out will disappoint, so maybe I need to purchase a computer with digital out, or a high end sound card?

Sorry if this is redundant to another thread that I may have missed.

Thanks.