Safely Using Pre Gain without Clipping

I have a WiiM Ultra streamer as my main source. If I’m using ReplayGain for my Qobuz and personal library listening, but not the WiiM's room correction or PEQ, is it safe to apply some positive adjustment in the WiiM's Pre Gain control under Inputs without causing distortion or clipping? I use an external room correction/bass management/tone control DSP (DSPeaker’s Anti-Mode X2D), and due to the use of the tone control feature to sumulate a Harman curve, I lose a substantial amount of gain, and with the VibeLink connecting digitally to the Anti-Mode’s output, I can’t just jam a preamp with active gain in there to get more gain. I am hoping that (at least theoretically) I can apply (maybe no more than +5dB) a positive gain in the WiiM Ultra's Pre Gain panel to get some gain back, especially since I use ReplayGain to help reduce big up or down volume changes between songs on my mixed playlists.

Anyone got advice and/or experience in general with positive settings in software preamp/DSP, especially used in conjunction with ReplayGain? In reality there are only a handful of tracks in my library where I currently peg volume at 100 and it’s still a smidge not loud enough (such as Karajan conducting Beethoven or Carmen performed by All-Star Percussion Ensemble…highly dynamic orchestral pieces that ought to be very loud when hitting peak passages), and they’re still just slightly less loud than I want to go.

-Ed