Running 2 systems in 1?

I’m probably going to get burned at the stake for this. Does anyone run 2 separate systems in the same room? I’m talking a tube amp/integrated, and SS on the same rack? Obviously it’s ok to have a digital source, AND run vinyl. But, anyone run different amps, and still have the ability to change it up? Much easier if one has a selection of standmount speaks..... crazy? I’m wanting to be able to change the sound in my listening room drastically, according to mood....
J.