Agree with soix, remote is likely the problem. Even if you had this problem with the OEM remote, it would likely be the remote. Not saying it couldn't be the receiver, but would look at the remote first.
Rotel RSX-1058 Won't Respond to Remote Commands
Have any forum members experienced a situation where your Rotel receiver suddenly stopped responding to remote commands? I haven't made any changes to my system, set-up or remote (I use a Logitech Harmony One) but my receiver is unresponsive to any and all remote commands. I haven't been able to find the OEM remote to perform a test but it seems more likely to be a problem with the receiver; it worked perfectly one minute than it just suddenly stopped responding. Any info on similar experiences is appreciated.