I have tried the VPI anti skating mechanism. I have also used the wire twist method. Harry states that very little AS force is needed for the 10.5 arm. I found that the VPI AS mechanism exerts too much force even at its lowest setting. I use 1 single twist of the tonearm wire. I find this to be the best solution for my setup. Yours may vary.
Remove your bias for better sound
I have a VPI Superscout rim drive and Classic platter, with VPI 10.5 arm and a Benz LPS cartridge. I had been using the anti-skate gizmo for some time, with only a minimal amount of exertion on the arm. I removed the gizmo, remounted the counterweight, just to try listen without the anti-skate. Much to my pleasure, the sound is much better with increased dynamic contrasts, cleaner mids, and more ease with the highs. I don't find that tracking is any less than with the gizmo installed. I recommend that all should try it. With the device still on the arm, but disconnected, there is only a very small increase in sound...remove the whole thing.