I try to keep my system simple.
Star configuration outlet for All your electronic, and this is Best direct from the wall if possible.
Start with your power distributør if you not have wall outlet star configuration. Your outlet distributor should then be a star configuration.
Then Source, i have a cd transport and a DAC. The DAC is the most importent of the TWO but Source first.
My integrated amp next. If i have had pre+amp combo, then the pre first and amp. second.
Then my speakers (Quad)
This is my experience.