That's a very broad question. All I can do for you is give you some opinions and facts. But the first thing I say is: listen for yourself!!!!!! If you find a speaker, no matter what kind of speaker it is, that you like (and can afford) buy it. One big difference between conventional (box) speakers and panelspeakers is that the latter is bi-directional, which means they are much more sensitive for room-placement. Also, most panelspeakers have a low sensitivity/high capacitance, which means they are not suited to low-output amps and/or amps that cannot deal with low capacities. On the plusside however, panelspeakers are capable of breathtaking soundstaging and treble-performance. Onfortunately, for an extended low-end performance large panels are needed. Maybe your best bet is to go for a hybrid system, something like a Martin-Logan, or maybe Quad ESL-63 with matching subwoofers.
