OP
Klipsh speakers are nice and you seem to be eyeing them. they sound great and sensitive so most amps will work with them, even if they are bit low powered TUBE.
as others have posted, listen to them first. but if you need to take leap of faith, then get the biggest one your budget will get you. another set of speakers are Mofi 888 source point speaker. i heard then sourcepoint 8 and that really is good. Lastly, since you are sticking to Mx110 pre, then i also will suggest the ATC SCM 19A active or for a bit more scm40A. i heard them and they are very very good dynamic speakers.
for Amps, i am a PassLab guy. Xa25 is my recommendation. or X150.8
for tubes I suggest the Line Magnetic amps that uses 845 tubes. they are a powerhouse of SET. (disclaimer, they run HOT). all the amps above i own
another amp that may be interesting are Gan Amps. i have not heard one but they say that it has the sound of a tube like
Listen/ Audition as much as you can before you make a jump