In general, I'd always say that two is better than one. And (see below) four may be better than two.
There are many excellent 12" subs out there for which a pair costs less than a single r 528. Both Rythmik (my choice) and SVS (highly regarded by many) offer a pair of 12" subs that will outperform the Rel on the test bench (not necessarily the same as sounding better). In each case, a pair sells for under $1500/pr. IIRC, the SVS is closer to $1100.
Duke, who posted above, owns Audiokinesis, which sells the Swarm bass system with four 8" subs for $2500. That might be one more good option to consider.
Lots of people love Rel, but I question the value proposition. Not trashing the brand - numbers never tell the whole story and personal preference varies - just suggesting that you might wish to explore some alternatives that offer more measured performance for less $.
As always, YMMV.
Marty