No doubt you will lose a little but if you have a beast of an amp you may be ok. 45ft isn’t crap in studios or live performances. If you can’t set your amp closer and use long XLR cables back to preamp then look at Canare. Unless you have Golden Ears you may not notice the difference regardless. Top end may get a little rolled off but I’d be more concerned about them working as antennas and picking up a lot of EM/RFI which is why I’m throwing out Canare as it is very good at canceling out noice being it’s primarily used in studios and pro audio. Canare 4S11 is a good cable regardless of cost.