I am running the DNA-500 with a VTL 5.5 pre to Maggie 3.6R's. I call it the velvet hammer, because the more the Maggie's ask for, the more you have to give. I also have a DNA-225 and DNA-1 Deluxe that I use with some Martin Logan's, but they are boys compared to this MAN. They are toys compared to the 500, although I loved each on the way to affording the DNA-500. I never had the DNA-2, but unless it's Steve's gold or plantinum edition, I think you'd probably be better off with the DNA-500. I do run it straight into it's own 20 Amp circuit so it has juice to go, with a Synergistic Master Couple PC. The question I'd ask would be what other components/speakers are you putting in front and behind it too? It matches with some things better than others, like everything in this busines.
