I think there is just something about a stand mounted small monitor (in my opinion a sub usually is needed) that works incredibly well.
The small surface area of the monitor with space all around allows a disappearing and imaging act that is hard to improve upon.
My current speakers are this kind of configuration. They can use their subwoofer cabinet as a stand, but getting them off and onto Sistrum stands just took the whole system to another level. Having the ability to position the woofers separately is also a bonus I think.
My current monitors are sealed as well (the separate subs are vented.)
If money were no object, I think I'd try the magico mini 2's with a pair of the Torus subs. About 8 times the cost of what I'm listening to now and probably a great match for my room size.
Actually hold it - the Scaena 3.2's I recently listened to pretty much topped everything I have heard. (I have not heard Kharma;s but have heard Marten's, 101E, Magico, etc)