I emailed customer service for Lyra USA: below is response
Dear Michael,
Bottom line is whichever way sounds best to you, that's the way it should be. As for anti-skate, it's there to counteract the force of the arm being dragged towards the middle of the record and to compensate for the stylus "hugging" the right hand groove wall. If you're sitting in the sweet spot and whatever information (such as vocals, usually) that's supposed to be in the center of the image is in the center of the image, then everything's fine. Leave it as is. If it sounds as though the balance control has been tweaked ever so slightly towards the right speaker, then maybe a touch of anti-skate is required.
Best regards,
Alasdair Patrick - Customer Service
Dear Michael,
Bottom line is whichever way sounds best to you, that's the way it should be. As for anti-skate, it's there to counteract the force of the arm being dragged towards the middle of the record and to compensate for the stylus "hugging" the right hand groove wall. If you're sitting in the sweet spot and whatever information (such as vocals, usually) that's supposed to be in the center of the image is in the center of the image, then everything's fine. Leave it as is. If it sounds as though the balance control has been tweaked ever so slightly towards the right speaker, then maybe a touch of anti-skate is required.
Best regards,
Alasdair Patrick - Customer Service