Blackie, one possibility you might explore is that the LAST preservative has actually broken loose contaminant in the grooves. As I understand the process (and I admit I may not have the details right), the LAST preservative actually penetrates the molecular surface of the vinyl. In the process, it can cause surface contaminant (dirt) to come loose that has not previously been removed. On the first play, the stylus picks this up. When I see this happen, I simply re-clean and rinse with great results. [In making this comment, I offer no disrespect to the Disc Doctor product, which has received high praise from many users whose opinions I respect.]
Other people who post here have previously noted this same experience. For example, see the post from Albert Porter at:
http://audiogo5.iserver.net/cgi-bin/fr.pl?eanlg&989893521&openflup&17&4#17