Your amplifier has balanced outputs, meaning that the negative speaker terminal has a full amplitude signal on it, rather than being grounded. So you should not connect the negative speaker-level input of a sub (which presumably is grounded within the sub through some relatively low impedance) to the negative output terminal of the amp. If you will be using two subs, connecting that wire from each sub to a chassis screw on the corresponding amp will most likely work well, and is what is recommended in the manuals for many REL subs.
If you will be using one sub which provides speaker-level inputs for two channels, as recommended in the REL manuals (when monoblock amps are being used) it would probably be best to connect that wire to a chassis screw or other ground point on the preamp. Although I can’t say that with certainty, as I’m not familiar with the technical details of the CAST interface you are using between the preamp and power amps.
In all of those cases the positive speaker-level inputs of the sub(s) would be connected to the positive output terminal of the amp for the corresponding channel.
Alternatively, given that the preamp’s CAST outputs are being used to connect to the amps you could connect the line-level inputs of the sub(s) to the preamp’s RCA outputs.
Regards,
-- Al