Rauliruegas has very good points on how to look at the LP system. So my answer is: it depends on your system and if your are playing mono or stereo!
My situation: I have a one TT/Arm system but play stereo with a Koetsu OPS in one B-44 arm wand and mono with Lyra Titian in second B-44 arm wand, I end up with two loadings two TFA's, and two VTA's. One setting for each - usually that's all. Have I tired more, yes. But the complications out-wade benefits on most records. The more anal you are the more you can do - it's just time, frustration and money.
My situation: I have a one TT/Arm system but play stereo with a Koetsu OPS in one B-44 arm wand and mono with Lyra Titian in second B-44 arm wand, I end up with two loadings two TFA's, and two VTA's. One setting for each - usually that's all. Have I tired more, yes. But the complications out-wade benefits on most records. The more anal you are the more you can do - it's just time, frustration and money.