How to run speaker wires...

This is probably more of a cabling question then it is a speaker question but is there a preferred/optimal way to run your speaker cables? What I mean is if you have say a dual voice coil speaker which would require 4 cables coming from the amp(provided you wire it parallel) would it be best to run both the positives side by side in a bundle and then do the same for the negative side, or would it be better to run the pairs each with 1 positive and 1 negative per bundle? Also on top of that, should you twist the pairs so as to create electromagnetic shielding the same way UTP Cat 5 computer cables are ran? Let me know your thoughts on this, thanks!