How do I get the most out of the Squeezebox Touch

I'm streaming music from the PC in my office to the audio system in my living room via the SBT. It sounds good but I'd like to improve it. I'm aware that I can run the SBT output through a better DAC but I'm thinking that will cost several times the price of the SBT in order to hear an improvement. Is there anything that I can do on the PC end prior to the signal leaving the PC. I'm aware of different players like Foobar, JRiver, etc. and enhancements to iTunes such as Pure Music but will any of these even matter since the files don't "play" through those interfaces.

Thanks