A new speaker rig in an unfamiliar room can be quite the challenge. You just have to work at it, and iterate. Get furnishings in there. Position, position, position. Experiment. Get external input. Have friends over. Explore acoustic treatments. DON’T go overboard there; it’s not necessary and nothing sucks more than trying to sell a pile of $$$$ treatments on the used market. There is no one-size-fits-all formula anyone can tell you for this.
If you have a great headphone setup, then yeah that’s gonna feel like an "easy button" for good sound compared to the initial struggle with speakers. Sadly, you might end up with a speaker / amp pairing you don’t dig, or the "wrong" speaker for a room, etc. At some point you can’t fix that and you’ll just have to try something else.
I’ll always keep around a great headphone setup. It’s how I got my start in this hobby, it’s a great reference / tool, and it’s perfectly capable of a joyful listening experience in its own right.