For me the acid test that any adjustment is moving in the right direction is whether it increases the diversity of scale and tonality in the reproduction. As you get things more optimized there should be greater variation in instrumental scale (i.e small instruments sound small and localized in space, and large instruments or massed strings say take up the appropriate space). This is true in two (L-R, F-B) and even three dimensions. In addition it should be easier to differentiate the tone of instruments, try separating strings in a string section, or isolating back up singers for example.
Sometimes this can strike you as a negative as the sound of something leaping out at you, spotlighted in a way, can be appealing but it's not natural (I'm of course talking about acoustic recordings here, studio artifice can create lots of effects but the well setup speaker should excel at teasing them apart).