One of my two anti-virus/anti-malware programs is the paid version of Malwarebytes (it saved my bacon many times). MWB has a superb ad-blocker which I use on Firefox, my primary browser. As a result, I haven't been served ads there in years. There's just one problem with this rosy picture: a number of websites are refusing to serve content unless I disable the blocker. This tactic is getting more robust and obstructive--they really mean business. I find in general that trying to set a permssion for certain websites to stream ads vs others just doesn't work. MWB has the functionality, but the website continue popping up the "Disable your ad-blocker" panels.
Not sure how to proceed, though in general I just avoid those websites on the believe that if they are that intrusive and pushy, I don't need whatever they have to gbegin with.